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Modafinil and antidepressants
New scientific work concluded that modafinil, which is usually used to treat sleep disorders, combined with antidepressants reduces the severity of depression more effectively than if you take only one antidepressant.
The study was conducted in collaboration between the universities of Cambridge and King's College, London, and was published online in the journal Clinical Psychiatry.
Approximately one third of patients with depression do not respond to antidepressant medication even when used in combination with counseling with a psychologist. In addition, the remaining two-thirds of patients report a side effect of antidepressants in the form of fatigue, fatigue and sleep problems, and often a relapse of depression.
The authors of the study believe that patients with depression will receive the maximum benefit from supplementing antidepressants with modafinil.
Professor Barbara Sahakyan from Cambridge University writes: "modafinil affects a number of neurotransmitters. This may explain why the addition of modafinil to conventional treatment with antidepressants, such as selective serotonin reuptake inhibitors, has a beneficial effect on the symptoms experienced by patients with depression. "
"This is good news for people who have been struggling with depression for a long time," said Professor Cynthia Fu of the University of East London, who took part in the study. "Depression affects all aspects of life, which leads to occupational and social disability at various levels. It is especially important that people receive effective treatment without residual symptoms such as fatigue, lack of concentration, etc. Which can persist when taking antidepressants. ".
For the study, the researchers studied previously published works that tested the use of modafinil as an additional treatment for depression. A total of 568 patients with unipolar depression and 342 patients with bipolar depression participated in the meta-analysis. The analysis showed that modafinil reduces the severity of depression, and also contributes to remission. Modafinil also showed a beneficial effect on fatigue and drowsiness, compared with the placebo group.
The study also showed that modafinil can also improve the functioning of the patient at work.
This is especially important, since depression is the main reason for missing a patient's work and preselection (present at work, but not functioning as before).
Dr. Musefer Keizer of the University of Cambridge adds: "We will conduct the following long-term trial to assess the potential benefits of supplementing antidepressants with modafinil, that is, more complexly."
Depression is one of the main health problems. According to the World Health Organization, depression will become the second cause of disability around the world by 2020. The annual cost of treating affective disorders in the UK is estimated at about 16 billion pounds sterling.